期刊
SCIENCE
卷 298, 期 5591, 页码 176-178出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1076196
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资金
- NIAID NIH HHS [U01AI48846, U01AI50687] Funding Source: Medline
- NIDCD NIH HHS [R01 DC04692-01, F31 DC05265-01A1, R01 DC004692] Funding Source: Medline
We used bioinformatic approaches to identify total of 276 G protein-coupled receptors (GPCRs) from the Anopheles gambiae genome. These include GPCRs that are likely to play roles in pathways affecting almost every aspect of the mosquito's life cycle. Seventy-nine candidate odorant receptors were characterized for tissue expression and, along with 76 putative gustatory receptors, for their molecular evolution relative to Drosophila melanogaster. Examples of lineage-specific gene expansions were observed as well as single instance of unusually high sequence conservation.
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