期刊
NEUROSCIENCE LETTERS
卷 331, 期 2, 页码 83-86出版社
ELSEVIER SCI IRELAND LTD
DOI: 10.1016/S0304-3940(02)00871-6
关键词
estrogen; glutamate; non-N-methyl-D-aspartate receptor; synaptic plasticity; evoked potentials
We examined the actions of estrogen on excitatory synaptic transmission in the basolateral amygdala (BLA), a brain region involved in learning, emotions, and the effects of stress. Intracellular recordings of monosynaptic excitatory postsynaptic potentials (EPSPs) were obtained from BLA neurons in a slice preparation. Bath application of 17beta-estradiol (2 muM) reduced EPSP amplitude by an average of 77%. This reduction was readily reversed by washing with control saline and was not mimicked by the inactive isomer 17alpha-estradiol. Other passive and active properties of BLA neurons were unaffected by 17beta-estradiol. The observed EPSP reduction is in sharp contrast to the potentiation of EPSPs by estrogen observed in other brain regions. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
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