Preparation of 6-chloro-5-fluoroindole via the use of palladium and copper-mediated heterocyclisations

The title indole, the heterocyclic core of the 5-HT2C receptor agonist Ro 60-0175, was prepared by it modification to the Stille indole synthesis, or by the method of Gonzalez and co-workers. (C) 2002 Elsevier Science Ltd. All rights reserved.