期刊
JOURNAL OF COLLOID AND INTERFACE SCIENCE
卷 254, 期 2, 页码 322-330出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1006/jcis.2002.8576
关键词
SAM; phosphorylated amino acid; phosphate layer; alkanethiols; gold; counterion influence
The synthesis of a series of thiols containing phosphorylated and non-phosphorylated serine, threonine, and tyrosine amino acid residues is described. The synthesized molecules, based on 3-mercaptopropionic acid, were assembled onto gold and subsequently characterized using infrared reflection-absorption spectroscopy, ellipsometry, X-ray photoelectron spectroscopy, and contact angle goniometry. The ellipsometric analysis indicates that they form densely packed and well-oriented monolayers on gold, with thicknesses that are in good agreement with estimated values from space-filling models. The bulky and space-demanding phosphorylated threonine analog was, however, found to be an exception. The increase in layer thickness when adding a phosphate group to the threonine is only 35% of that observed for the two other analogs. A detailed infrared examination of the influence of cation coordination to the phosphorylated serine analog using calcium and magnesium reveals structural similarities to those of the inorganic phosphate compound calcium hydroxy apatite. We furthermore discuss the application of these monolayers as soft templates for biomineralization. (C) 2002 Elsevier Science (USA).
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