期刊
REGULATORY PEPTIDES
卷 108, 期 2-3, 页码 165-173出版社
ELSEVIER
DOI: 10.1016/S0167-0115(02)00099-X
关键词
VIP; PACAP; VPAC receptors; G protein-coupled receptor (GPCR); class II GPCR; site-directed mutagenesis; receptor chimeras; structural modeling
VIP and PACAP are two prominent neuropeptides which share two common G protein-coupled receptors VPAC1 and VPAC2 while PACAP has an additional specific receptor PAC1. This paper reviews the present knowledge regarding three aspects of VPAC receptors including: (i) receptor specificity towards natural VIP-related peptides and pharmacology of synthetic agonists or antagonists; (ii) receptor signaling; (iii) molecular basis of ligand-receptor interaction as determined by site-directed mutagenesis, construction of receptor chimeras and structural modeling. (C) 2002 Elsevier Science B.V. All rights reserved.
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