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Design and synthesis of activity probes for glycosidases

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卷 4, 期 21, 页码 3607-3610

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AMER CHEMICAL SOC
DOI: 10.1021/ol0265315

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[GRAPHICS] A new synthetic route was developed for the preparation of activity probe 1 for beta-glucosidase in this study. The key glycosidation step begins with benzyl p-hydroxyphenylacetate. Benzylic functionalization for the construction of the trapping device was achieved at later stages. Probe 1 was shown to be able to label the target enzyme. This cassette-like design offers great flexibility for future alterations. It would allow the synthetic scheme to expand to other glycosidase probes with different linker/reporter combinations.

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