期刊
CIRCULATION RESEARCH
卷 91, 期 8, 页码 672-680出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/01.RES.0000037000.74258.03
关键词
GPCR; adrenergic; heptahelical; arrestin; phosphorylation
资金
- NHLBI NIH HHS [HL70631, HL64713, HL16037] Funding Source: Medline
- NIGMS NIH HHS [GM60982] Funding Source: Medline
The actions of many hormones and neurotransmitters are mediated through stimulation of G protein-coupled receptors. A primary mechanism by which these receptors exert effects inside the cell is by association with heterotrimeric G proteins, which can activate a wide variety of cellular enzymes and ion channels. G protein-coupled receptors can also interact with a number of cytoplasmic scaffold proteins, which can link the receptors to various signaling intermediates and intracellular effectors. The multicomponent nature of G protein-coupled receptor signaling pathways makes them ideally suited for regulation by scaffold proteins. This review focuses on several specific examples of G protein-coupled receptor-associated scaffolds and the roles they may play in organizing receptor-initiated signaling pathways in the cardiovascular system and other tissues.
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