期刊
VETERINARY MICROBIOLOGY
卷 89, 期 2-3, 页码 167-179出版社
ELSEVIER
DOI: 10.1016/S0378-1135(02)00169-4
关键词
vaccines; chicken-bacteria; Salmonella enterica serotypes Enteritidis and Typhimurium; challenge models; colonisation; Salenvac (R) T
A commercial inactivated iron restricted Salmonella Typhimurium and Salmonella Enterifidis vaccine was used to vaccinate chicks at I day and again at 4 weeks of age, with challenge by a high and a low dose of S. Typhimurium given either orally or by contact with seeder birds inoculated orally with a high dose of S. Typhimurium. In all three challenge regimes, the shedding of challenge strain was reduced significantly (p < 0.05) in vaccinated birds compared with unvaccinated controls. Vaccination reduced colonisation of internal organs after challenge by contact seeder birds. However, no effect of vaccination upon colonisation of internal organs after either high or low oral challenge was apparent. In conclusion, the data indicate that the vaccine should be a useful tool in the control of S. Typhimurium infection in chickens. (C) 2002 Elsevier Science B.V. All rights reserved.
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