期刊
FEBS LETTERS
卷 531, 期 1, 页码 93-98出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0014-5793(02)03484-1
关键词
glycosphingolipid; microdomain; tumor cell motility; CD9; signal transducer; activation; sensor; collagen gel; invasion
资金
- NCI NIH HHS [CA80054] Funding Source: Medline
Two human mammary carcinoma cell variants, MCF-7/AZ and MCF-7/6, show the same composition in their glycosphingolipid-enriched microdomain (GEM) with regard to globo-series structures Gb3, Gb4, Gb5, monosialyl-Gb5, GM2, and cSrc and FAK. Both variants are non-invasive into collagen gel layer, and showed similar motility in wound migration assay. Whereas invasiveness and motility of MCF-7/AZ cells were enhanced greatly by treatment with mAb RM1 directed to monosialyl-Gb5, the same RM1 treatment had no effect on MCF-7/6. cSrc and FAK of MCF-7/AZ, but not MCF-7/6, were activated by RM1 treatment. Thus, malignancy of MCF-7 is highly dependent on monosialyl-Gb5, and its activation of cSrc and FAK in GEM. (C) 2002 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.
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