Preparation and study on the solid inclusion complex of ciprofloxacin with β-cyclodextrin

The interaction of ciprofloxacin with beta-cyclodextrin (beta-CD) has been studied by several analytical techniques, including H-1-NMR (nuclear magnetic resonance), C-13-NMR, fluorescence spectroscopy, infrared (IR) spectroscopy, thermal analysis, and scanning electron microscope. in this paper, solid inclusion complex of ciprofloxacin with beta-CD was synthesized by the coprecipitation method. In addition, the characterization of the inclusion complex has been proved by fluorimetry, IR, differential scanning calorimetry and 1D, 2D NMR. The experimental results confirmed the existence of 1: 1 inclusion complex of ciprofloxacin with beta-CD. The formation constant of complex was determined by fluorescence method and H-1-NMR. Spatial configuration of complex has been proposed on two dimensional NMR technique. (C) 2002 Elsevier Science B.V. All rights reserved.