期刊
IMMUNOLOGICAL REVIEWS
卷 189, 期 -, 页码 123-135出版社
BLACKWELL MUNKSGAARD
DOI: 10.1034/j.1600-065X.2002.18911.x
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Upon antigen recognition, T cells undergo substantial membrane and cytoskeletal rearrangements that lead to the formation of the immunological synapse and are necessary for subsequent T-cell activation. However, little is known about how membrane and cytoskeletal molecules interact during these processes. Here we discuss the involvement of the membrane-microfilament linker ezrin. We propose that ezrin is a component of the cytoskeleton-mediated architecture of the immunological synapse that plays a role in T-cell receptor clustering, protein kinase C theta translocation and intracellular signaling.
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