期刊
MEDICAL AND PEDIATRIC ONCOLOGY
卷 39, 期 5, 页码 519-523出版社
WILEY-LISS
DOI: 10.1002/mpo.10178
关键词
hepatocellular carcinoma; childhood cancer; adult oncology; cancer treatment; cancer biology; prognostic factors
Background. Differences in the biology, natural history, and treatment results of hepatocellular carcinoma (HCC) in children and adults were sought based on the literature and experience resulting from SIOPEL 1 trial. Procedure. In the SIOPEL 1 study, 40 children with HCC were registered from January 1990 to February 1994. Outcome was analyzed in 39, In most cases, disease was advanced at diagnosis: 31% had metastases and 39% had extrahepatic tumor extension and/or vascular invasion. More than 50% of patients had multifocal tumors; 39% of tumors were associated with hepatic cirrhosis. All, but two patients, received preoperative chemotherapy (PLADO-cisplatin and doxorubicin), Outcome, response to treatment, and prognostic factors were analyzed using the SAS statistical package. Results. Overall survival (OS) at 5 years is 28% and EFS is 17% at median follow-up of 75 months (49-90). Partial response to chemotherapy was observed in 18 of 37 cases evaluated (49%). Complete tumor resection was achieved in 14 of the 39 patients (36%). Twenty (51%) never became operable. Multifocality of the tumor, presence of metastases, and PRETEXT grouping adversely influenced OS. A large number of de novo HCC cases, fairly high response rate to preoperative chemotherapy (49%) and 54% survival after complete resection constitute a significant difference in comparison with adult HCC series. Conclusions. Survival for pediatric HCC patients is below 30%. Radical tumor resection remains the only chance for survival. New multi-center prospective studies in children with HCC are required to better results and to allow further study of differences between adult and pediatric HCC should they exist. (C) 2002 Wiley-Liss, Inc.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据