期刊
JOURNAL OF BACTERIOLOGY
卷 184, 期 22, 页码 6130-6137出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JB.184.22.6130-6137.2002
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资金
- NIGMS NIH HHS [R01 GM047296, GM47296] Funding Source: Medline
Together, the biosyntheses of histidine, purines, and thiamine pyrophosphate (TPP) contain examples of convergent, divergent, and regulatory pathway integration. Mutations in two purine biosynthetic genes (purI and purH) affect TPP biosynthesis due to flux through the purine and histidine pathways. The molecular genetic characterization of purI mutants and their respective pseudorevertants resulted in the conclusion that <1% of the wild-type activity of the Purl enzyme was sufficient for thiamine but not for purine synthesis. The respective pseudorevertants were found to be informational suppressors. In addition, it was shown that accumulation of the purine intermediate aminoimidazole carboxamide ribotide inhibits thiamine synthesis, specifically affecting the conversion of aminoimidazole ribotide to hydroxymethyl pyrimidine.
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