期刊
VACCINE
卷 20, 期 31-32, 页码 3650-3657出版社
ELSEVIER SCI LTD
DOI: 10.1016/S0264-410X(02)00396-1
关键词
Yersinia pestis; V antigen; interferon-gamma; interleukin-4; interleukin-6; PLLA microspheres
We have investigated intranasal delivery of novel vaccines for plague, based on poly-L-lactide (PLLA) microencapsulated recombinant V antigen (rV) of Yersinia pestis. Microspheres containing rV alone or co-encapsulated with the cytokines IFN-gamma, IL-4 or IL-6 were administered in a two-dose regimen and antibody responses and protective efficacy were monitored. All treatment groups stimulated high rV-specific antibody titres in serum, predominantly of the IgG1 isotype, which were maintained over several months. There was evidence of both IgG and IgA responses in lung samples from all groups. Formulations based on rV antigen alone or rV co-encapsulated with IL-6 provided complete protection against systemic challenge with Y. pestis strain GB; however protective efficacy was impaired by co-encapsulating either IFN-gamma or IL-4 with rV. Crown Copyright (C) 2002 Published by Elsevier Science Ltd. All rights reserved.
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