期刊
DEVELOPMENTAL CELL
卷 3, 期 5, 页码 673-684出版社
CELL PRESS
DOI: 10.1016/S1534-5807(02)00327-1
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资金
- NIGMS NIH HHS [R01 GM58017] Funding Source: Medline
The maternally expressed C. elegans gene spd-5 encodes a centrosomal protein with multiple coiled-coil domains. During mitosis in mutants with reduced levels of SPD-5, microtubules assemble but radiate from condensed chromosomes without forming a spindle, and mitosis fails. SPD-5 is required for the centrosomal localization of gamma-tubulin, XMAP-215, and Aurora A kinase family members, but SPD-5 accumulates at centrosomes in mutants lacking these proteins. Furthermore, SPD-5 interacts genetically with a dynein heavy chain. We propose that SPD-5, along with dynein, is required for centrosome maturation and mitotic spindle assembly.
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