期刊
AMERICAN JOURNAL OF EPIDEMIOLOGY
卷 156, 期 9, 页码 806-812出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/aje/kwf129
关键词
folic acid; hypertension; pre-eclampsia; pregnancy; vitamins
资金
- NHLBI NIH HHS [HL50763] Funding Source: Medline
- NICHD NIH HHS [HD27697] Funding Source: Medline
The authors investigated the association between folic acid supplementation and gestational hypertension. The study population included women with nonmalformed infants in the United States and Canada who were participating in the Slone Epidemiology Center Birth Defects Study between 1993 and 2000. Women were interviewed within 6 months after delivery about sociodemographic and medical factors, the occurrence of hypertension with or without preeclampsia, and multivitamin use in pregnancy. Relative risks, adjusted for weight, parity, twin pregnancy, diabetes, smoking, education, and family income, were estimated using Cox regression models. Of 2,1100 women, 204 (9.7%) reported gestational hypertension (onset after the 20th week of gestation), The multivariate-adjusted relative risk of developing gestational hypertension during the month after folic acid supplementation, compared with not using folic acid during that same month, was 0.55 (95% confidence interval: 0.39, 0.79). This finding suggests that folic acid-containing multivitamins may reduce the risk of gestational hypertension.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据