期刊
JOURNAL OF ETHNOPHARMACOLOGY
卷 83, 期 1-2, 页码 153-159出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/S0378-8741(02)00205-2
关键词
cyclooxygenase-2 (COX-2); inducible nitric oxide synthase (iNOS); natural products; lipopolysaccharide (LPS); prostaglandin E-2; RAW264.7 cells
The inhibitors of prostaglandin biosynthesis and nitric oxide production have been considered as potential anti-inflammatory and cancer chemopreventive agents. In this study, we evaluated approximately 170 methanol extracts of natural products including Korean herbal medicines for the inhibition of prostaglandin E-2 production (for COX-2 inhibitors) and nitric oxide formation (for iNOS inhibitors) in lipopolysaccharide (LPS)-induced mouse macrophages RAW264.7 cells. As a result, several extracts such as Aristolochia debilis, Cinnamomum cassia, Cinnamomum loureirii, Curcuma zedoaria, Eugenia caryophyllata, Pterocarpus santalius, Rehmania glutinosa and Tribulus terrestris showed potent inhibition of COX-2 activity (> 80% inhibition at the test concentration of 10 mug/ml). In addition, the extracts of A. debilis, Caesalpinia sappan, Curcuma longa, C. zedoaria, Daphne genkwa and Morus alba were also considered as potential inhibitors of iNOS activity (> 70% inhibition at the test concentration of 10 mug/ml). These active extracts mediating COX-2 and iNOS inhibitory activities are warranted for further elucidation of active principles for development of new cancer chemopreventive and/or anti-inflammatory agents. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
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