期刊
PEDIATRIC PULMONOLOGY
卷 34, 期 5, 页码 375-377出版社
WILEY
DOI: 10.1002/ppul.10185
关键词
acute tubular necrosis; adverse effects; cystic fibrosis; drug monitoring; inhaled tobramycin; renal failure; aerosolized tobramycin
We describe a 20-year-old patient with cystic fibrosis who developed acute nonoliguric renal failure associated with inhaled tobramycin. Clinical evaluation and renal biopsy findings were consistent with aminoglycoside-induced changes. Renal failure due to inhaled aminoglycosides has not been previously reported. The incidence may rise, however, with the increased use of this treatment modality. Measurable tobramycin levels due to inhalational therapy with conventional dosing in the reported patient indicate that the drug can be systemically absorbed, and renal tubular toxicity may occur. (C) 2002 Wiley-Liss,Inc.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据