期刊
MOLECULAR BIOTECHNOLOGY
卷 22, 期 3, 页码 301-315出版社
HUMANA PRESS INC
DOI: 10.1385/MB:22:3:301
关键词
proteomics; de novo sequencing; database searching; tandem mass spectrometry
There are many computer programs that can match tandem mass spectra of peptides to database-derived sequences; however, situations can arise where mass spectral data cannot be correlated with any database sequence. In such cases, sequences can be automatically deduced de novo, without recourse to sequence databases, and the resulting peptide sequences can be used to perform homologous nonexact searches of sequence databases. This article describes details on how to implement both a de novo sequencing program called Lutefisk, and a version of FASTA that has been modified to account for sequence ambiguities inherent in tandem mass spectrometry data.
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