期刊
BEHAVIOR GENETICS
卷 32, 期 6, 页码 435-443出版社
KLUWER ACADEMIC/PLENUM PUBL
DOI: 10.1023/A:1020884312053
关键词
mice; genetics; body size; feeding; drinking; lateralization
资金
- NIAAA NIH HHS [R01 AA012715, AA-12715] Funding Source: Medline
- NIDCD NIH HHS [DC-03853, R01 DC000882] Funding Source: Medline
- NIDDK NIH HHS [R01 DK046791, DK-46791, R01 DK094759, R01 DK046791-12, DK-058797, R01 DK058797] Funding Source: Medline
Male mice from 28 inbred strains (129P3/J, A/J, AKR/J, BALB/cByJ, BUB/BnJ, C3H/HeJ, C57BL/6J, C57L/J, CAST/Ei, CBA/J, CE/J, DBA/2J, FVB/NJ, I/LnJ, KK/HIJ, LP/J, NOD/LtJ, NZB/BINJ, P/J, PL/J, RBF/DnJ, RF/J, RIIIS/J, SEA/GnJ, SJL/J, SM/J, SPRET/Ei, and SWR/J) were fed chow and had access to two water bottles. Body weight, food intake, water intake, and drinking spout side preference were measured. There were large strain differences in all the measures collected, with at least a two-fold difference between strains with the lowest and the highest trait values. Estimates of heritability ranged from 0.36 (spout side preference) to 0.87 (body weight). Body weight, food intake, and water intake were interrelated among the strains, although substantial strain variation in food and water intakes independent from body weight was present. The strain differences described here provide useful information for designing mutagenesis screens and choosing strains for genetic mapping studies.
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