期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 132, 期 1-2, 页码 66-71出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0165-5728(02)00310-7
关键词
glucocorticoid resistance; LPS; CD11b; social disruption; monocyte/macrophage; corticosterone
资金
- NIAID NIH HHS [AI 48995] Funding Source: Medline
- NIDCR NIH HHS [DE13749-01] Funding Source: Medline
- NIMH NIH HHS [MH46801-08] Funding Source: Medline
Social stress of group-housed male mice induced a state of functional glucocorticoid (GC) resistance in splenocytes. The following studies examined the effects of paired-fighting (PF) stress on immune cell distribution and function in spleens of male mice. Following six daily PF stress sessions, splenic monocytes and neutrophils increased and lymphocytes decreased. PF also altered the distribution of CD62L and CD11b positive monocytes. Additionally, PF augmented proliferation and lowered the sensitivity of LPS-stimulated splenocytes to the antiproliferative effects of corticosterone, suggesting that PF induced a state of GC resistance in splenocytes. Together, these findings indicate that social stress altered phenotype and function of splenic immune cells. These findings may have implications for the healing of bite wounds that are often associated with social stress in rodents. (C) 2002 Elsevier Science B.V. All rights reserved.
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