期刊
JOURNAL OF NUTRITION
卷 132, 期 11, 页码 3418-3421出版社
OXFORD UNIV PRESS
DOI: 10.1093/jn/132.11.3418
关键词
folate deprivation; hyperhomocysteinemia; cerebral microvascular wall; neurotoxicity; rats
We investigated the effects of folate deprivation on plasma folate and homocysteine and its effects on cerebral microvasculature using electron microscopy. Two levels of folic acid (0 mg and 4 mg/kg diet) were fed to 6-mo-old male rats for 8 wk. Dietary folate deprivation decreased plasma folate from 353.0 +/- 29.7 nmol/L to 44.2 +/- 7.2 nmol/L with a concomitant increase in plasma homocysteine from 6.15 +/- 0.9 mumol/L to 19.5 +/- 2.7 mumol/L. Plasma folate was negatively correlated with plasma homocysteine at wk 8 (r = -0.876, P = 0.004). Electron microscopic studies of the brains of folate-deprived rats revealed cytoplasmic swelling and mitochondrial degeneration in the endothelium, perivascular amorphous fibrosis and pericytic degenerative appearance in the cerebrocortical microvascular wall. These morphologic changes might be helpful for elucidating the mechanisms underlying the cerebrovascular and neuropathology with folate deficiency.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据