Stabilization of atherosclerotic plaques: New mechanisms and clinical targets

Research points to pivotal roles for lipids in the development of atherosclerotic plaques. Lipid-lowering statins substantially reduce acute coronary events resulting from plaque development, but only modestly reduce arterial stenosis. This apparent paradox has shifted the goal of therapy toward plaque stabilization rather than enlargement of the lumen. More thorough understanding to the biology of atherosclerosis should enable us to manipulate plaque stability, and reduce further the acute complications of atherosclerosis.