期刊
BLOOD
卷 100, 期 9, 页码 3077-3086出版社
AMER SOC HEMATOLOGY
DOI: 10.1182/blood-2002-04-1104
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资金
- NHLBI NIH HHS [R56 HL067336, R01 HL067336, R01 HL020899, HL 20899, R01 HL020899-23, HL 67336] Funding Source: Medline
- NIDDK NIH HHS [DK 53510, DK 61804, R01 DK061805, R01 DK061804, DK 61805] Funding Source: Medline
Locus control regions (LCRs) are operationally defined by their ability to enhance the expression of linked genes to physiological levels in a tissue-specific and copy number-dependent manner at ectopic chromatin sites. Although their composition and locations relative to their cognate genes are different, LCRs have been described in a broad spectrum of mammalian gene systems, suggesting that they play an important role in the control of eukaryotic gene expression. The discovery of the LCR in the beta-globin locus and the characterization of LCRs in other loci reinforces the concept that developmental and cell lineage-specific regulation of gene expression relies not on gene-proximal elements such as promoters, enhancers, and silencers exclusively, but also on long-range interactions of various cis regulatory elements and dynamic chromatin alterations. (C) 2002 by The American Society of Hematology.
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