Cyclization of nitriles:: LIX.: Synthesis and properties of 1-(2-thienyl)-4-cyano-5,6,7,8-tetrahydro-3(2H)-isoquinolinethione derivatives.: Molecular and crystal structure of 3-isobutylsulfanyl-1-(2-thienyl)-4-cyano-5,6,7,8-tetrahydroisoquinoline

By condensation of 2-(2-thenoyl)-1-cyclohexanone with cyanothioacetamide a new compound of a series of chalcogen-containing isoquinolines with a thiophene fragment in its structure was prepared. It was demonstrated that alkylation of the compound with haloalkanes and their derivatives, in particular with those having electron-withdrawing substituents furnished 3-alkylthio-4-cyano-5,6,7,8-tetrahydroisoquinolines. Some of the latter underwent cyclization into 3-amino-2-R-5-(2-thienyl)-6,7,8,9-tetrahydrothieno[2,3-c]-isoquinoline.