期刊
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
卷 45, 期 13, 页码 1097-1102出版社
WILEY
DOI: 10.1002/jlcr.627
关键词
preparation; P-32-labeled; AIR; CAIR; AICAR; adenosine kinase
A fast and efficient route to P-32-labeled intermediates on the purine biosynthetic pathway is described. Adenosine kinase catalyzes the phosphorylation of 5-aminoimidazole-4-carboxamide ribonucleoside (AICARs) to give [P-32]-5-aminoimidazole-4-carboxamide ribonucleotide (AICAR). This was then hydrolyzed to [P-32]-4-carboxy-5-aminoimidazole ribonucleotide (CAIR). Treatment of CAIR with N5-CAIR mutase gave [P-32]-5-aminoimidazole ribonucleotide (AIR) in milligram quantities. Copyright (C) 2002 John Wiley Sons, Ltd.
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