Dopamine receptor expression on human T- and B-lymphocytes, monocytes, neutrophils, eosinophils and NK cells: a flow cytometric study

This study documents expression of dopamine (DA) receptors on leukocyte subpopulations using flow cytometric techniques to identify dopamine receptors with subtype-specific antibodies. Of the D1-like receptor family (D-1 and D-5), only D-5 was detected, and of the D2-like receptor family (D-2, D-3 and D-4), all dopamine receptors were detected. T-lymphocytes and monocytes had low expression of dopamine receptors, whereas neutrophils and eosinophils had moderate expression. B cells and NK cells had higher and more consistent expression. Dopamine receptors D-3 and D-5 were found in most individuals whereas D-2 and D-4 had more variable expression. D-1 was never found. (C) 2002 Elsevier Science B.V. All rights reserved.