期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 132, 期 1-2, 页码 140-146出版社
ELSEVIER
DOI: 10.1016/S0165-5728(02)00324-7
关键词
iron overload; Cryptocoecus neoformans; meningoencephalitis; immune response
This study was aimed at investigating the effects of iron overload on the onset and outcome of cerebral cryptococcosis. To this purpose, iron dextran-administered mice were intracerebrally challenged with virulent melanogenic and avirulent non-melanogenic strains of Cryptococcus neoformans. The results shown here provide the first evidence that iron overload exacerbates the outcome of cryptococcal meningoencephalitis, irrespective of the fungal strain employed; pathogen colonization of the brain is facilitated, local cytokine response is delayed and/or prevented. (C) 2002 Elsevier Science B.V All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据