期刊
EUROPEAN JOURNAL OF NEUROLOGY
卷 9, 期 -, 页码 1-6出版社
WILEY
DOI: 10.1046/j.1468-1331.9.s3.1.x
关键词
levodopa; levodopa-induced dyskinesia; Parkinson's disease; serotonin
While Parkinson's disease is undoubtedly a disorder with a primary pathology of dopamine neuronal loss, that loss of dopamine and subsequent dopamine replacement therapy leads to imbalances in many non-dopaminergic transmitter systems, including 5-hydroxytryptamine (5-HT). Recent advances in understanding the role of 5-HT in parkinsonism and the generation of side-effects of dopamine replacement therapy (e.g. wearing-off and levodopa-induced dyskinesia) have identified 5-HT1A, 5-Ht(1B) and 5-HT2C receptors as potential therapeutic targets in Parkinson's disease.
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