期刊
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
卷 68, 期 11, 页码 5769-5772出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AEM.68.11.5769-5772.2002
关键词
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In the filamentous fungus Aspergillus nidulans, iron homeostasis is regulated at the transcriptional level by the negative-acting GATA factor SREA. In this study the expression of a putative heme-containing metalloreductase-encoding gene, freA, was found to be upregulated by iron limitation independently of SREA, demonstrating the existence of an iron-regulatory mechanism which does not involve SREA. In contrast to freA, various other genes encoding proteins in need of iron-containing cofactors-acoA, lysF, and cycA-were downregulated in response to iron depletion. Remarkably, SREA deficiency led to increased expression of acoA, lysF, and cycA under iron-replete growth conditions.
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