期刊
FREE RADICAL RESEARCH
卷 36, 期 11, 页码 1139-1146出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/1071576021000016391
关键词
superoxide; free radical; epilepsy; mitochondria
资金
- NINDS NIH HHS [R01NS39587] Funding Source: Medline
Epilepsy is a common and heterogeneous neurological disorder arising from biochemical and molecular events that are incompletely understood. To effectively manage epilepsies, it is important to understand the mechanisms underlying both seizure-induced brain damage as well as seizure initiation. Oxidative stress is emerging as a mechanism that may play an important role in the etiology of seizure-induced neuronal death. Conversely, epileptic seizures are a common occurrence in mitochondrial diseases arising from defects in oxidative phosphorylation. This review focuses on the emerging role of oxidative stress and mitochondrial dysfunction both as a consequence and cause of epileptic seizures.
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