期刊
JOURNAL OF NEUROLOGY
卷 249, 期 11, 页码 1535-1540出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00415-002-0884-0
关键词
Parkinson's disease; autonomic nervous system; heart rate variability; circadian fluctuation
Parkinson's disease is known to affect the reflex cardiovascular control systems, resulting in a suppressed heart rate variability, but present knowledge concerning the long-term characteristics of heart rate and heart rate variability, e. g. circadian regulation, is limited. We investigated the circadian fluctuation of the time domain, frequency domain and some non-linear measures of heart rate variability in 44 untreated patients with Parkinson's disease and 43 age- and sex-matched control subjects. In the parkinsonian patients, the measured power spectral components of heart rate variability (low-frequency power and high-frequency power) and the SD1 value of the Poincare two dimensional vector analysis, that quantifies the short term beat-to-beat variability, were suppressed at night. During the daytime only the SD1 of the Poincare was suppressed. The night-to-day-ratios of the heart rate variability measures did not differ significantly between the patients and the controls. The results indicate that the long-term parasympathetic cardiovascular regulation is impaired in untreated patients with Parkinson's disease. The dysfunction is more pronounced at night.
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