期刊
CHEMOSPHERE
卷 49, 期 6, 页码 539-544出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0045-6535(02)00387-9
关键词
pharmaceuticals; PhACs; residues; groundwater; drinking water; contamination
Residues of three phenazone-type pharmaceuticals have been identified in routine analyses of groundwater samples from selected areas in the north-western districts of Berlin, Germany. Phenazone, propiphenazone, and dimethyl-aminophenazone have been detected in some wells at concentrations up to the low mug/1-level. Additionally, three phenazone-type metabolites namely 1-acetyl-1-methyl-2-dimethyl-oxamoyl-2-phenyihydrazide (AMDOPH), 1-acetyl-1-methyl-2-phenylhydrazide, and dimethyloxalamide acid-(N'-methyl-N-phenyl)-hydrazide have also been identified in these groundwater samples. The residues are suspected to originate from former production spills of a pharmaceutical plant located in a city north of Berlin. It was observed that with the exception of AMDOPH all other residues were efficiently removed during conventional drinking water treatment. The drug metabolite AMDOPH deriving from dimethylaminophenazone residues was found at concentrations of 0.9 mug/1 in finished drinking water. However, a following study on the toxicological relevance of the AMDOPH residues has shown that there is no toxicological harm for humans at the low concentrations of AMDOPH observed in Berlin drinking water. (C) 2002 Elsevier Science Ltd. All rights reserved.
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