期刊
AMERICAN JOURNAL OF HUMAN GENETICS
卷 71, 期 5, 页码 1183-1188出版社
UNIV CHICAGO PRESS
DOI: 10.1086/343819
关键词
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资金
- NHGRI NIH HHS [R01 HG00848, R01 HG000848] Funding Source: Medline
Because of the large number of tests for linkage that are performed in genome scans, the naive estimator of the size of a genetic effect in cases of borderline significance can be inflated and lead to unrealistic expectations for successful replication. As a remedy, this report proposes lower confidence limits that account for the multiple comparisons of the genome scan.
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