期刊
FARMACO
卷 57, 期 11, 页码 897-908出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/S0014-827X(02)01302-2
关键词
4-alkoxy-6-methyl-1H-pyrrolo[3,4-c]pyridine-1,3(2H)-diones; N-[2-hydroxy-3-(4-aryl-1-piperazinyl)propyl] derivatives; synthesis; analgesic and sedative activities; derivatives of 7-aza-4-azoniaspiro[3.5]nonane chloride
Synthesis of 2-[2-hydroxy-3-(4-aryl-1-piperazinyl)propyl] derivatives of 4-alkoxy-6-methyl-1H-pyrrolo[3,4-c]pyridine-1,3(2H)diones (8-12) is described. The chlorides used in the above synthesis can exist in two isomeric forms: chain (18-20) and cyclic (19a, 20a). The compounds 8-12 exhibited potent analgesic activity which was superior than that of acetylsalicylic acid in two different tests. Most of the investigated imides suppressed significantly spontaneous locomotor activity in mice. (C) 2002 Editions scientifiques et medicales Elsevier SAS. All rights reserved.
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