期刊
MOLECULAR CELL
卷 10, 期 5, 页码 1223-1233出版社
CELL PRESS
DOI: 10.1016/S1097-2765(02)00702-5
关键词
-
资金
- NIGMS NIH HHS [GM 42421, GM 18926, GM 23674] Funding Source: Medline
The temporal firing of replication origins throughout S phase in yeast depends on unknown determinants within the adjacent chromosomal environment. We demonstrate here that the state of histone acetylation of surrounding chromatin is an important regulator of temporal firing. Deletion of RPD3 histone deacetylase causes earlier origin firing and concurrent binding of the replication factor Cdc45p to origins. In addition increased acetylation of histories in the vicinity of the late origin ARS1412 by recruitment of the histone acetyltransferase Gcn5p causes ARS1412 alone to fire earlier. These data indicate that histone acetylation is a direct determinant of the timing of origin firing.
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