期刊
JOURNAL OF LIPID RESEARCH
卷 43, 期 11, 页码 1770-1772出版社
ELSEVIER
DOI: 10.1194/jlr.C200010-JLR200
关键词
KK/San; intravenous injection; plasma triglyceride
Studies with KK/San, obese and diabetic model mice having a unique hypotriglyceridemia phenotype, revealed that angiopoietin-like protein 3 (ANGPTL3) regulates lipid metabolism in mice. To determine the lipid-modulating role of other ANGPTLs, we focused on ANGPTL4, which overall shows a significant similarity to ANGPTL3. Surprisingly, an intravenous injection of the ANGPTL4 protein in KK/San mice rapidly increased the circulating plasma lipid levels at a higher rate than ANGPTL3 protein. Furthermore, the ANGPTL4 protein inhibited the lipoprotein lipase activity in vitro.
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