期刊
XENOTRANSPLANTATION
卷 9, 期 6, 页码 376-381出版社
BLACKWELL MUNKSGAARD
DOI: 10.1034/j.1399-3089.2002.02138.x
关键词
Gal alpha 1; 3Gal; Hanganutziu-Deicher; humans; N-acetylneuraminic acid; natural antibodies; N-glycolylneuraminic acid
The first and major clinical obstacle in xenotransplantation is antibody-mediated hyperacute rejection. Although human natural antibodies against Galalpha1,3Gal (Gal) antigens, which are common on porcine cells and organs, have been identified to play a major role in hyperacute rejection, other natural antibodies against non-Gal epitopes may be also involved in the process. Here, we present evidence suggesting that the majority of human anti-non-Gal antibodies are specific for carbohydrate structures carrying terminally linked N-glycolylneuraminic acid (NeuGc), a xenoantigen existing in almost all animals except humans. Furthermore, this anti-NeuGc activity is detectable in 85% of healthy humans, implicating the involvement of NeuGc in hyperacute rejection and the importance of developing strategies for removing NeuGc for clinical xenotransplantation.
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