4.4 Article

ATP and control of intracellular growth of mycobacteria by T cells

期刊

INFECTION AND IMMUNITY
卷 70, 期 11, 页码 6456-6459

出版社

AMER SOC MICROBIOLOGY
DOI: 10.1128/IAI.70.11.6456-6459.2002

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资金

  1. NHLBI NIH HHS [HL 59558] Funding Source: Medline
  2. NIAID NIH HHS [AI 27243, N01AI95383, K08 AI001581, R01 AI027243, K08 AI 01581, P30 AI036219, AI 95383, AI-36219] Funding Source: Medline
  3. NIGMS NIH HHS [GM 36387, R01 GM036387] Funding Source: Medline

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Extracellular ATP at millimolar concentrations inhibits growth of mycobacteria in human macrophages. Whether T cells can produce sufficient ATP is unknown. CD4(+) and CD8(+) T cells did not release sufficient ATP through either degranulation or lysis of bystander cells to restrict growth of Mycobacterium bovis BCG in monocytes.

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