期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 12, 期 21, 页码 3073-3076出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0960-894X(02)00659-5
关键词
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The combination of a 3,5-bis(trifluoromethyl)phenyl needle with the spiropyrrolo-pyrrole motive as a privileged GPCR scaffold was the basis for designing a focused combinatorial library targeted towards the neurokinin-1 receptor. A solution- and solid-phase method is described and binding affinities of representative compounds are presented. (C) 2002 Elsevier Science Ltd. All rights reserved.
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