期刊
JOURNAL OF EXPERIMENTAL MEDICINE
卷 196, 期 9, 页码 1189-1199出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20021110
关键词
B lymphocytes; memory; complement receptors; Fc gamma RIIB; follicular dendritic cells
资金
- PHS HHS [A139246] Funding Source: Medline
To dissect the influence of CD21/CD35 and FcgammaRIIB in antigen retention and Immoral memory, we used an adoptive transfer model in which antigen-primed B and T lymphocytes were given to sublethally irradiated wild-type mice or mice deficient in CD21/CD35 (Cr2(-/-)) or FcgammaRIIB receptors (FcgammaRIIB(-/-)). Cr2(-/-) chimeras showed impaired memory as characterized by a decrease in antibody titer, reduced frequency of antibody secreting cells, an absence of affinity maturation, and significantly reduced recall response. The impaired memory in Cr2(-/-) chimeras corresponded with the reduced frequency of antigen-specific memory B cells. Interestingly, FcgammaRIIB(-/-) chimeras showed a differential phenotype with impaired splenic but normal bone marrow responses. These data suggest that CD21/CD35 on stroma, including follicular dendritic cells, is critical to the maintenance of long-term B lymphocyte memory.
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