Rapid synthesis of a glycosylphosphatidylinositol-based malaria vaccine using automated solid-phase oligosaccharide synthesis

Described is an automated synthesis of hexasaccharicle malarial toxin 1, currently under development as a malaria vaccine candidate. Using a combination of automated solid-phase methods and solution-phase fragment coupling, the target glycosylphosphaticlylincisitol was assembled in a matter of days, compared with several weeks for a comparable solution-phase synthesis.