Protein-cleaving catalyst selective for protein substrate

[GRAPHICS] A protein-cleaving catalyst specific for a disease-related protein can be used as a catalytic drug. As the first Protein-cleaving catalyst selective for a protein substrate, a catalyst for myoglobin was designed by attaching Cu(II) or Co(III) complex of cyclen to a binding site searched by a combinatorial method using peptide nucleic acid monomers as building units.