期刊
NEUROSCIENCE LETTERS
卷 333, 期 1, 页码 5-8出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/S0304-3940(02)00915-1
关键词
amyloid beta(1-40); amyloid beta(25-35); neurotoxicity; chrysamine G; half chrysamine G
The neurotoxicity of amyloid beta (Abeta) is widely believed to play a seminal role in neurodegeneration in Alzheimer's disease. We examined the effect of Chrysamine G (CG) on such neurotoxicity using the specific measurement of surviving neurons. CG was found to reduce the neurodegeneration induced by both the active short fragment of Abeta(25-35) and full-sized Abeta(1-40). In this study, we synthesized a new chemical compound from a monovalent structure of CG (hCG), with a lower affinity for Abeta, and compared its activity with that of CG. Both CG and hCG were found to be equally efficacious in reducing Abeta-induced neuronal death at a concentration of 0.1-1 muM, indicating that the mechanism of action for CG was not due to its chelating activity, but rather due to its anti-oxidant activity. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
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