5-HT1A receptor antagonist administration decreases cell proliferation in the dentate gyrus

This study investigated the action of 5-HT1A receptor antagonists on cell proliferation in the dentate gyrus of adult rats. Three antagonists (NAN-190, p-MPPI and WAY-100635) all produced a statistically significant similar to30% reduction in the number of BrdU-immunoreactive cells in the dentate gyrus. This suggests that 5-HT1A receptor activity is important during naturally occurring cell proliferation in the dentate gyrus, and perhaps neurogenesis, and is one of the many factors involved in its regulation. (C) 2002 Elsevier Science B.V. All rights reserved.