期刊
JOURNAL OF CELL SCIENCE
卷 115, 期 22, 页码 4201-4214出版社
COMPANY BIOLOGISTS LTD
DOI: 10.1242/jcs.00106
关键词
basement membrane collagens; NC1 fragments; angiogenesis; morphogenesis
类别
资金
- NCI NIH HHS [CA72006, P01 CA072006, P01 CA072006-040003] Funding Source: Medline
- NIAMS NIH HHS [R01 AR046238-03, AR46238, R01 AR046238] Funding Source: Medline
- NINDS NIH HHS [R01 NS039278, R01 NS039278-06, NS39278] Funding Source: Medline
Collagens IV, XV and XVIII are major components of various basement membranes. In addition to the collagen-specific triple helix, these collagens are characterized by the presence of several non-collagenous domains. It is clear now that these ubiquitous collagen molecules are involved in more subtle and sophisticated functions than just the molecular architecture of basement membranes, particularly in the context of extracellular matrix degradation. Degradation of the basement membrane collagens occurs during numerous physiological and pathological processes such as embryonic development or tumorigenesis and generates collagen fragments. These fragments are involved in the, regulation of functions differing from those of their original intact molecules. The non-collagenous C-terminal fragment NC1 of collagen IV, XV and XVIII have been recently highlighted in the literature because of their potential in reducing angiogenesis and tumorigenesis, but it is clear that their biological functions are not limited to these processes Proteolytic release of soluble NC1 fragments stimulates migration, proliferation, apoptosis or survival of different cell types and suppresses various morphogenetic events.
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