期刊
VACCINE
卷 21, 期 1-2, 页码 115-119出版社
ELSEVIER SCI LTD
DOI: 10.1016/S0264-410X(02)00399-7
关键词
OPV vaccine; statistics; monkey neurovirulence test; central nervous system
Prior to batch release of oral poliovirus vaccines (OPV) for marketing purpose, the World Health Organisation (WHO) and European pharmacopoeia require a monkey neurovirulence test to be performed both by the manufacturer and the relevant National Control Laboratory (NCL) to assess vaccine safety as regards neurovirulence. Due to the subjectivity of histological examination and of neural lesions scoring, the French NCL has set up a proficiency testing procedure to qualify a new expert. (C) 2002 Elsevier Science Ltd. All rights reserved.
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