期刊
VACCINE
卷 21, 期 1-2, 页码 138-145出版社
ELSEVIER SCI LTD
DOI: 10.1016/S0264-410X(02)00348-1
关键词
serum response; cholera vaccine; technique
Serum responses to oral cholera vaccines were assessed in three paediatric vaccine trials, two in Leon, Nicaragua and one in Stockholm, Sweden. A calibrated anti-cholera toxin B subunit (CTB) IgA ELISA was used together with an assay for vibriocidal antibodies. Swedish children had lower pre-vaccination levels of antibody, but serum responses were more pronounced in Swedish children than in Nicaraguan children. Post-vaccination levels of anti-toxin antibody were generally above those found after natural infections with enterotoxigenic Escherichia coli, that cross-reacts serologically with Vibrio cholerae. Adverse events seen after vaccination were generally mild and of little clinical significance. (C) 2002 Elsevier Science Ltd. All rights reserved.
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