期刊
SCIENCE
卷 298, 期 5598, 页码 1600-1602出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1077353
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The reversible blockage of synthetic pores formed by rigid-rod beta barrels, either by substrates or products, was used to sense a variety of enzymatic reactions in high-throughput format with naked-eye fluorescent detection. Improvement of sensor sensitivity beyond three orders of magnitude by straightforward internal mutations underscores the functional plasticity of rigid-rod beta barrels. Such detectors of enzyme activity with the aforementioned characteristics are needed in areas as diverse as proteomics and environmentally benign organic synthesis.
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