期刊
CANCER LETTERS
卷 185, 期 2, 页码 173-179出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/S0304-3835(02)00277-X
关键词
interferon (IFN)-alpha; IFN-alpha 8; subtype; chronic myelogenous leukaemia (CML); Fas
类别
Here we report on the anti-tumor effects of five interferon (IFN)-alpha subtypes, alpha1, alpha2, alpha5, alpha8, and alpha10 in chronic myelogenous leukaemia (CML)-derived cell lines. All of the CML cells can respond to IFN-alpha although the anti-tumor effects of IFN-alpha depend on the target cell and on the type of IFN-alpha subtype used. Proliferation assays showed that IFN-alpha8 was substantially more effective than the other four IFN-alpha subtypes. IFN-alpha8 was the most potent at upregulating immunomodulatory molecule expression while IFN-alpha1 was least potent. These data indicate in vitro distinctions between IFN-alpha subtypes that should be appreciated more in the clinic. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
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